BAPTA-AM is a rationally-designed relative of the well-known chelator EGTA. BAPTA-AM and its analogs have a 100-fold greater affinity for Ca2+ over Mg2+, are resistant to pH changes, and are faster in uptake and release of Ca2+. [1] BAPTA-AM, the acetic acid methyl ester analog of the original BAPTA, offers greater cell permeability and is known to inactivate protein kinase C.