Strontium ranelate (Protelos), a strontium (II) salt of ranelic acid, is an agent for the treatment of osteoarthritis and osteoporosis. Classified as a dual-action bone agent (DABA), strontium ranelate is unique in that it can simultaneously inhibit bone resorption and stimulate bone formation. [1]

More specifically, strontium ranelate increases in vitro osteoblast differentiation from progenitors, as well as osteoblast-induced osteoclastogenesis both in vitro and in vivo. Regarding bone-antiresorbing mechanisms, strontium ranelate decreases osteoclast differentiation and activity, while increasing their apoptosis. [2]

Strontium ranelate (Protelos), a strontium (II) salt of ranelic acid, is an agent for the treatment of osteoarthritis and osteoporosis. Classified as a dual-action bone agent (DABA), strontium ranelate is unique in that it can simultaneously inhibit bone resorption and stimulate bone formation. [1]

More specifically, strontium ranelate increases in vitro osteoblast differentiation from progenitors, as well as osteoblast-induced osteoclastogenesis both in vitro and in vivo. Regarding bone-antiresorbing mechanisms, strontium ranelate decreases osteoclast differentiation and activity, while increasing their apoptosis. [2]