Cefdinir is an orally-available, b-lactam antibiotic that binds to penicillin-susceptible Staphylococcus aureus 2132 at an MIC of 25 nM (1) and E. Coli C11 at an MIC of 63 nM (ED50 of 1.32 mg/kg) (2) In contrast to other oral cephalosporins, cefdinir retains substantial activity against a panel of bacterial strains and is found to be extremely stable against numerous b-lactamases. Additionally, cefdinir inhibits the adherence of type-1 fimbriated E. coli to uroepithelial cells. (3)

In clinical studies, cefdinir has been shown to be superior to pencillin V and comparable to cephalexin and amoxicillin/clavulanate in the treatment of both pediatric and adult bacterial infections. (3)