(-)-ITD-1 is a resolved enantiomer of ITD-1 that possesses significantly less TGF-β inhibition and cardiogenesis compared to either racemic ITD-1 or (+)-ITD-1. Compared to racemic ITD-1 or (+)-ITD-1, (-)-ITD-1 can serve as a control for non-specific effects of ITD-1. (-)-ITD-1 has been formulated as a salt to increase stability and improve water solubility (~0.1 mg/mL) for ease of handling. As a salt, (-)-ITD-1 is chemically and metabolically stable and can be used as a control in the study a wide range of biological studies in cellular processing and TGF-β signaling.

(-)-ITD-1 is a resolved enantiomer of ITD-1 that possesses significantly less TGF-β inhibition and cardiogenesis compared to either racemic ITD-1 or (+)-ITD-1. Compared to racemic ITD-1 or (+)-ITD-1, (-)-ITD-1 can serve as a control for non-specific effects of ITD-1. (-)-ITD-1 has been formulated as a salt to increase stability and improve water solubility (~0.1 mg/mL) for ease of handling. As a salt, (-)-ITD-1 is chemically and metabolically stable and can be used as a control in the study a wide range of biological studies in cellular processing and TGF-β signaling.