KHS101 binds to TACC3, which is a structural component of the centrosome and mitotic spindle apparatus, prevents its ability to sequester ARNT2 in the cytoplasm. A study performed in rats showed KHS101 is a small molecule that can induce neural differentiation by inhibiting NPC maintenance, while also stabilizing proneurogenesis transcriptional pathways. KHS101 can accelerate neural differentiation from the progenitor pool by blocking self-renewal.

KHS101 binds to TACC3, which is a structural component of the centrosome and mitotic spindle apparatus, prevents its ability to sequester ARNT2 in the cytoplasm. A study performed in rats showed KHS101 is a small molecule that can induce neural differentiation by inhibiting NPC maintenance, while also stabilizing proneurogenesis transcriptional pathways. KHS101 can accelerate neural differentiation from the progenitor pool by blocking self-renewal.