LDN193189 is a highly potent BMP inhibitor, prevents Smad1, Smad5, and Smad8 phosphorylation through inhibition of BMP type I receptors ALK2 (IC50=5nM) and ALK3 (IC50=30 nM). Its inhibitions against ALK4, ALK5, and ALK7 are weak (IC50 >500 nM). As BMP signaling coordinates developmental patterning and has essential physiological roles in mature organisms, LDN-193189 is used to reduce ectopic ossification in a mouse model.

Product Citation