
Cellagen Technology
DNA intercalator
Pirarubicin is an anthracycline drug used to treat various types of cancer. It intercalates between base pairs and interacts with topoisomerase II, therefore inhibiting DNA replication and repair and RNA synthesis. Compared with its analog Adriamycin (Doxorubicin), Pirarubicin is less cardiotoxic than doxorubicin and exhibits activity against some doxorubicin-resistant cell lines. (1,2)


(8S,10S)-10-(((2R,4S,5S,6S)-4-amino-6-methyl-5-(((R)-tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)
-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione

Cellagen Technology
DNA intercalator


Pirarubicin is an anthracycline drug used to treat various types of cancer. It intercalates between base pairs and interacts with topoisomerase II, therefore inhibiting DNA replication and repair and RNA synthesis. Compared with its analog Adriamycin (Doxorubicin), Pirarubicin is less cardiotoxic than doxorubicin and exhibits activity against some doxorubicin-resistant cell lines. (1,2)
(8S,10S)-10-(((2R,4S,5S,6S)-4-amino-6-methyl-5-(((R)-tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)
-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione