A769662 is a potent, reversible AMP-activated protein kinase (AMPK) activator. It activates AMPK through the β subunit carbohydrate-binding module and the γ subunit but not the AMP-binding sites.

A769662 stimulated partially purified rat liver AMPK with an EC50 of 0.8 µM and inhibited fatty acid synthesis in primary rat hepatocytes with an IC50 of 3.2 µM. A769662 could be a useful tool compound for both cell survival and cell proliferation.