LDN-57444 is a specific inhibitor (Ki = 0.4 ?M) against Ubiquitin carboxy-terminal hydrolase L1 (UCH-L1), a member of deubiquitinating enzymes (DUBs). LDN-57444 increased proliferation of SH-SY5Y cells, a UCH-L1-expressing neuroblastoma line. [1]

As expression of UCH-L1 is highly specific to neurons and to cells of the diffuse neuroendocrine system and their tumors, LDN-57444 is a useful tool for studying the roles of UCH-L1 in Alzheimer??s disease, Parkinson??s disease, and other neurological disorders. [2,3]